(S,R,S)-AHPC-amido-C7-acid

Names

[ CAS No. ]:
2172819-76-8

[ Name ]:
(S,R,S)-AHPC-amido-C7-acid

Biological Activity

[Description]:

(S,R,S)-AHPC-amido-C7-acid incorporates a VHL ligand for the E3 ubiquitin ligase and a PROTAC linker. (S,R,S)-AHPC-amido-C5-acid can be used to design PROTACs[1].

[Related Catalog]:

Research Areas >> Cancer
Signaling Pathways >> PROTAC >> E3 Ligase Ligand-Linker Conjugate

[References]

[1]. Sun N, et al. Discovery of the First Lactate Dehydrogenase Proteolysis Targeting Chimera Degrader for the Treatment of Pancreatic Cancer. J Med Chem. 2023 Jan 12;66(1):596-610.  

Chemical & Physical Properties

[ Molecular Formula ]:
C31H44N4O6S

[ Molecular Weight ]:
600.77

Related Compounds