Nampt-IN-9

Names

[ CAS No. ]:
2180973-35-5

[ Name ]:
Nampt-IN-9

Biological Activity

[Description]:

Nampt-IN-9 (Compound 8) is a potent NAMPT inhibitor with anticancer activities. Nampt-IN-9 can be used for pancreatic ductal adenocarcinoma research[1].

[Related Catalog]:

Research Areas >> Cancer
Signaling Pathways >> Metabolic Enzyme/Protease >> Nampt

[In Vitro]

Nampt-IN-9 (Compound 8) shows anti-proliferative activity with IC50 values of 0.8, 0.5, 0.004 and 0.6 nM against Jurkat, MIA PaCa-2, BxPC-3, PANC-1 cells, respectively[1]. Nampt-IN-9 (0-1 μM) blunts NAD+ and ATP levels and activates caspase 3 in Jurkat leukemia cells[1].

[References]

[1]. Bai JF, et al. Identification of new FK866 analogues with potent anticancer activity against pancreatic cancer. Eur J Med Chem. 2022 Jun 2;239:114504.

Chemical & Physical Properties

[ Molecular Formula ]:
C26H33N3O4

[ Molecular Weight ]:
451.56

Related Compounds