β2AR/M-receptor agonist-1

Names

[ CAS No. ]:
2230520-62-2

[ Name ]:
β2AR/M-receptor agonist-1

Biological Activity

[Description]:

β2AR/M-receptor agonist-1 (example 131) is a muscarinic antagonist and β2 adrenoceptor agonist (MABA). β2AR/M-receptor agonist-1 shows potency to β2 adrenoceptor with an EC50 value of 9.2 nM. β2AR/M-receptor agonist-1 also has potency to muscarinic receptor with a Ki value of 30.2 nM. β2AR/M-receptor agonist-1 shows MABA potency with an EC50 value of 4.0 nM[1].

[Related Catalog]:

Signaling Pathways >> Neuronal Signaling >> mAChR
Research Areas >> Cardiovascular Disease
Signaling Pathways >> GPCR/G Protein >> mAChR
Signaling Pathways >> GPCR/G Protein >> Adrenergic Receptor

[In Vivo]

β2AR/M-receptor agonist-1 (0.01 和 0.1 mg/kg；静脉注射，一次) 降低比格犬的心率[1]。

[References]

[1]. WEN SHOUMING, et al. CLASS OF BIFUNCTIONAL COMPOUNDS WITH QUATERNARY AMMONIUM SALT STRUCTURE. WO2018108089. 2018.

Chemical & Physical Properties

[ Molecular Formula ]:
C43H56BrN3O7

[ Molecular Weight ]:
806.82

Related Compounds