KRAS inhibitor-14
Names
[ CAS No. ]:
2230873-78-4
[ Name ]:
KRAS inhibitor-14
Biological Activity
[Description]:
KRAS inhibitor-14 (compound 3-22) is a potent KRAS G12C inhibitor with an IC50 of 0.249 µM. KRAS inhibitor-14 shows p-ERK inhibition activities with IC50s of 1.12, >33.3 µM in MIA PaCA-2, A549 cells, respectively. KRAS inhibitor-14 has the potential for the research of pancreatic, colorectal, and lung cancers[1].
[Related Catalog]:
[Target]
KRas G12C:0.249 μM (IC50)
[References]
Chemical & Physical Properties
[ Molecular Formula ]:
C20H15Cl3FN3O2S
[ Molecular Weight ]:
486.77