HIV-1 protease-IN-2
Names
[ CAS No. ]:
2248124-46-9
[ Name ]:
HIV-1 protease-IN-2
Biological Activity
[Description]:
HIV-1 protease-IN-2 is a potent HIV-1 protease inhibitor with an IC50 of 2.53 nM. HIV-1 protease-IN-2 shows antiviral activity against DRV (Darunavir)-sensitive or DRV-resistant HIV-1 variants[1].
[Related Catalog]:
[Target]
IC50: 2.53 nM (HIV-1 protease)[1]
[In Vitro]
HIV-1 protease-IN-2 (compound 10e) (100 nM) shows a promising inhibition ratio of 68% at 100 nM for wild-type HIV-1[1]. HIV-1 protease-IN-2 (0-1000 nM) shows antiviral activity against DRV (Darunavir)-sensitive or resistant pseudotyped HIV-1 with EC50s of 0.27 µM and 0.59 µM for HIV-1NL4-3 and HIVRDRVS, respectively[1].
[References]
Chemical & Physical Properties
[ Molecular Formula ]:
C27H34N4O7S
[ Molecular Weight ]:
558.65