KRAS G12C inhibitor 47

Names

[ CAS No. ]:
2253119-24-1

[ Name ]:
KRAS G12C inhibitor 47

Biological Activity

[Description]:

KRAS G12C inhibitor 47 (compound 8-1-1) is a potent KRAS G12C inhibitor with an IC50 of 0.172 µM. KRAS G12C inhibitor 47 shows p-ERK inhibition activities with IC50s of 0.046, 69.8 µM in MIA PaCA-2, A549 cells, respectively. KRAS G12C inhibitor 47 has the potential for the research of pancreatic, colorectal, and lung cancers[1].

[Related Catalog]:

Research Areas >> Cancer
Signaling Pathways >> GPCR/G Protein >> Ras

[Target]

KRas G12C:0.172 μM (IC50)


[References]

[1]. Brian alan, et al. KRAS g12c inhibitors and methods of using the same. WO2018119183 A2

Chemical & Physical Properties

[ Molecular Formula ]:
C30H28ClFN4O3

[ Molecular Weight ]:
547.02

Related Compounds