PI3Kα-IN-6

Names

[ CAS No. ]:
2272894-14-9

[ Name ]:
PI3Kα-IN-6

Biological Activity

[Description]:

PI3Kα-IN-6 (Compound 5b) is a PI3Kα inhibitor. PI3Kα-IN-6 exhibits anticancer potential and no toxicity in normal cells. PI3Kα-IN-6 increases generation of ROS, reduces mitochondrial membrane potential (MMP) and induces apoptosis[1].

[Related Catalog]:

Signaling Pathways >> Apoptosis >> Apoptosis
Research Areas >> Cancer
Signaling Pathways >> PI3K/Akt/mTOR >> PI3K
Signaling Pathways >> Protein Tyrosine Kinase/RTK >> ROS

[Target]

PI3Kα


[In Vitro]

PI3Kα-IN-6 (Compound 5b) shows cell growth inhibition with IC50 values of 3.5, 8.7, 8.9, 26.5, 89.9, 61.1 and 112.02 against HCT-116, A-549, MiaPaca-2, MCF-7, MDA-MB-231, PC-3 and HEK-293 cells, respectively[1].

[References]

[1]. Singh D, et al. Synthesis of 3-N-/O-/S-methyl-imidazo[1,2-a] pyridine derivatives for caspase-3 mediated apoptosis induced anticancer activity.

Chemical & Physical Properties

[ Molecular Formula ]:
C16H15IN2OS

[ Molecular Weight ]:
410.27

Related Compounds