ACC1/2-IN-1

Names

[ CAS No. ]:
2350219-22-4

[ Name ]:
ACC1/2-IN-1

Biological Activity

[Description]:

ACC1/2-IN-1 (compound 4s) is a potent ACC1/2 inhibitor with IC50 values of 98.06 and 29.43 nM for ACC1 and ACC2, respectively. ACC1/2-IN-1 can be used for cancer research[1].

[Related Catalog]:

Research Areas >> Cancer
Signaling Pathways >> Metabolic Enzyme/Protease >> Acetyl-CoA Carboxylase

[In Vitro]

ACC1/2-IN-1 (compound 4s) (72 hours; tumor cell lines) has anti-proliferative activity against A549, H1975, HCT116 and H7901 cell lines with IC50 values of 0.578, 1.005, 0.680 and 1.406 μΜ, respectively[1].

[References]

[1]. Wei Q, et al. Design, synthesis and biological evaluation of novel chroman derivatives as non-selective acetyl-CoA carboxylase inhibitors. Bioorg Chem. 2020 Aug;101:103943.

Chemical & Physical Properties

[ Molecular Formula ]:
C34H32N4O4

[ Molecular Weight ]:
560.64

Related Compounds