COX-1/2-IN-1

Names

[ CAS No. ]:
2358849-47-3

[ Name ]:
COX-1/2-IN-1

Biological Activity

[Description]:

COX-1/2-IN-2 is a potent COX1/2 inhibitor. COX-1/2-IN-2 exhibits significant inhibitory effect against COX-1 and COX-2 inhibitor with IC50 values of 13.9 ± 3.21 µM and 6.4±0.74 µM, respectively[1].

[Related Catalog]:

Research Areas >> Inflammation/Immunology
Signaling Pathways >> Immunology/Inflammation >> COX

[Target]

COX-1:9.7±0.09 μM (IC50)

COX-2:4.6±1.45 μM (IC50)


[References]

[1]. Malose J. Mphahlele, et al. Synthesis, in vitro and in silico enzyme (COX-1/2 & LOX-5), free radical scavenging and cytotoxicity profiling of the 2,4-dicarbo substituted quinazoline 3-oxides. Medicinal Chemistry Research volume 31, pages146–164 (2022)

Chemical & Physical Properties

[ Molecular Formula ]:
C15H10BrClN2O

[ Molecular Weight ]:
349.61

Related Compounds