Thalidomide-NH-PEG3-CH2CHO

Names

[ CAS No. ]:
2360530-43-2

[ Name ]:
Thalidomide-NH-PEG3-CH2CHO

Biological Activity

[Description]:

Thalidomide-NH-PEG3-CH2CHO is the Thalidomide-based Cereblon ligand used in the recruitment of CRBN protein. Thalidomide-NH-PEG3-CH2CHO can be connected to the ligand for protein by a linker to form PROTAC BCL-XL degrader XZ739 (HY-133557)[1].

[Related Catalog]:

Research Areas >> Cancer
Signaling Pathways >> PROTAC >> Ligand for E3 Ligase

[Target]

Cereblon


[References]

[1]. Xuan Zhang,et al. Discovery of PROTAC BCL-X L Degraders as Potent Anticancer Agents With Low On-Target Platelet Toxicity. Eur J Med Chem. 2020 Apr 15;192:112186.

Chemical & Physical Properties

[ Molecular Formula ]:
C21H25N3O8

[ Molecular Weight ]:
447.44

Related Compounds