BRM/BRG1 ATP Inhibitor-3
Names
[ CAS No. ]:
2368901-31-7
[ Name ]:
BRM/BRG1 ATP Inhibitor-3
Biological Activity
[Description]:
BRM/BRG1 ATP Inhibitor-3 is a BRG1/BRM inhibitor. BRM/BRG1 ATP Inhibitor-3 inhibits BRM and BRG1 with IC50 values of 10.4 nM and 19.3 nM, respectively. BRM/BRG1 ATP Inhibitor-3 can be used for the research of cancers and BAF complex-related disorders[1].
[Related Catalog]:
[Target]
IC50: 10.4 nM (BRM); 19.3 nM (BRG1)[1].
[In Vitro]
BRM/BRG1 ATP Inhibitor-3 has inhibitory activity for BRM and BRG1 with IC50 values of 10.4 nM and 19.3 nM, respectively[1]. BRM/BRG1 ATP Inhibitor-3 (0.01-10 μM) has inhibition for cell proliferation in several cancer cell lines[1]. Cell Proliferation Assay[1] Cell Line: Uveal melanoma cell lines (92-1 , MP41 , MP38, MP46), prostate cancer cell lines (LNCAP), lung cancer cell lines (NCI-H1299), and immortalized embryonic kidney lines (HEK293T) Concentration: 0-10 μM Incubation Time: 3 days Result: Inhibited cell proliferation of uveal melanoma cell line 92-1 and MP41.
[References]
Chemical & Physical Properties
[ Molecular Formula ]:
C26H25N5O2S2
[ Molecular Weight ]:
503.64