c-Met-IN-13

Names

[ CAS No. ]:
2377724-93-9

[ Name ]:
c-Met-IN-13

Biological Activity

[Description]:

c-Met-IN-13 is a potent c-Met inhibitor with an IC50 value of 2.43 nM. c-Met-IN-13 shows excellent cytotoxicity for cancer cells. c-Met-IN-13 shows antiproliferative activity in a concentration- and time- dependent manner. c-Met-IN-13 has the potential for the research of cancer[1].

[Related Catalog]:

Research Areas >> Cancer
Signaling Pathways >> Protein Tyrosine Kinase/RTK >> c-Met/HGFR

[Target]

c-Met:2.43 nM (IC50)


[In Vitro]

c-Met-IN-13 (compound 10m) shows cytotoxic activities with IC50s of 0.14, 0.20, 0.26 µM for H460, HT-29, MKN-45, respectively[1]. c-Met-IN-13 shows tyrosine kinases selectively with IC50s of 4.42, 6.15, 18.64, 295, 540, >10000, 2.43 nM for c-kit, Flt-3,Ron, VEGFR-2, Flt-4, EGFR, C-Met, respectively[1]. c-Met-IN-13 (0-300 µg/ml; 72 h) shows antiproliferative activity in a concentration and time dependent manner[1].

[References]

[1]. Nan X, et al. Structure-based discovery of novel 4-(2-fluorophenoxy)quinoline derivatives as c-Met inhibitors using isocyanide-involved multicomponent reactions. Eur J Med Chem. 2020 May 1;193:112241.

Chemical & Physical Properties

[ Molecular Formula ]:
C30H28F2N2O6

[ Molecular Weight ]:
550.55

Related Compounds