IDO1/TDO-IN-1

Names

[ CAS No. ]:
2379527-72-5

[ Name ]:
IDO1/TDO-IN-1

Biological Activity

[Description]:

IDO1/TDO-IN-1 (30) is a potent dual IDO1 (uncompetitive, Ki of 0.23 μM) and TDO (competitive, Ki of 0.73 μM) inhibitor. IDO1/TDO-IN-1 (30) significantly promotes cell apoptosis through the potential mitochondria-mediated Bcl-2/Bax pathway[1].

[Related Catalog]:

Signaling Pathways >> Apoptosis >> Bcl-2 Family
Signaling Pathways >> Apoptosis >> Apoptosis
Research Areas >> Cancer
Signaling Pathways >> Metabolic Enzyme/Protease >> Indoleamine 2,3-Dioxygenase (IDO)

[Target]

IDO1:0.23 μM (Ki)

TDO:0.73 μM (Ki)


[References]

[1]. Jiangxin Liu, et al. Discovery and biological evaluation of tanshinone derivatives as potent dual inhibitors of indoleamine 2, 3-dioxygenase 1 and tryptophan 2, 3-dioxygenase. Eur J Med Chem. 2022 May 5;235:114294.

Chemical & Physical Properties

[ Molecular Formula ]:
C21H16O6

[ Molecular Weight ]:
364.35

Related Compounds