FGFR4-IN-11

Names

[ CAS No. ]:
2396664-85-8

[ Name ]:
FGFR4-IN-11

Biological Activity

[Description]:

FGFR4-IN-11 (Compound 30) is a potent, selective, covalent FGFR4 inhibitor with an IC50 of 2.1 nM. FGFR4-IN-11 significantly inhibits the FGF19/FGFR4 signaling pathway and shows antitumor activity[1].

[Related Catalog]:

Research Areas >> Cancer
Signaling Pathways >> Protein Tyrosine Kinase/RTK >> FGFR

[Target]

FGFR4:2.1 nM (IC50)


[References]

[1]. Zhong Z, et al. Discovery of Novel 7-Azaindole Derivatives as Selective Covalent Fibroblast Growth Factor Receptor 4 Inhibitors for the Treatment of Hepatocellular Carcinoma. J Med Chem. 2022 May 26;65(10):7278-7295.

Chemical & Physical Properties

[ Molecular Formula ]:
C29H29N5O5

[ Molecular Weight ]:
527.57

Related Compounds