BuChE-IN-5

Names

[ CAS No. ]:
2402753-39-1

[ Name ]:
BuChE-IN-5

Biological Activity

[Description]:

BuChE-IN-5 (compound 25b) is a potent BuChE inhibitor with an IC50 value of 1.94 μM. BuChE-IN-5 efficiently inhibits aggregation Aβ and tau protein in Escherichia coli. BuChE-IN-5 also has free radical scavenging capacity and antioxidant activity. BuChE-IN-5 can be used for researching Alzheimer’s disease[1].

[Related Catalog]:

Research Areas >> Neurological Disease
Signaling Pathways >> Neuronal Signaling >> AChE

[Target]

Butyrylcholinesterase:1.94 μM (IC50)


[References]

[1]. Wichur T, et al. 1-Benzylpyrrolidine-3-amine-based BuChE inhibitors with anti-aggregating, antioxidant and metal-chelating properties as multifunctional agents against Alzheimer's disease. Eur J Med Chem. 2020 Feb 1;187:111916.

Chemical & Physical Properties

[ Molecular Formula ]:
C25H35N3

[ Molecular Weight ]:
377.57

Related Compounds