Mt KARI-IN-4

Names

[ CAS No. ]:
2413974-53-3

[ Name ]:
Mt KARI-IN-4

Biological Activity

[Description]:

Mt KARI-IN-4 (compound 5c) is a potent Mycobacterium tuberculosis ketol-acid reductoisomerase (Mtb KARI) inhibitor with a Ki value of 5.48 μM. Mt KARI-IN-4 has inhibitory activity against Mtb H37Rv (MIC = 0.78 μM) and low cytotoxicity (HEK IC50 > 72 μg/mL)[1].

[Related Catalog]:

Research Areas >> Infection
Signaling Pathways >> Anti-infection >> Bacterial

[Target]

Ki: 5.48 μM (Mtb KARI)[1]


[References]

[1]. Krishna VS, et al. Design and development of ((4-methoxyphenyl)carbamoyl) (5-(5-nitrothiophen-2-yl)-1,3,4-thiadiazol-2-yl)amide analogues as Mycobacterium tuberculosis ketol-acid reductoisomerase inhibitors. Eur J Med Chem. 2020;193:112178.

Chemical & Physical Properties

[ Molecular Formula ]:
C13H8FN5O3S2

[ Molecular Weight ]:
365.36

Related Compounds