Adenylyl cyclase type 2 agonist-1

Names

[ CAS No. ]:
2414908-52-2

[ Name ]:
Adenylyl cyclase type 2 agonist-1

Biological Activity

[Description]:

Adenylyl cyclase type 2 agonist-1 (Compound 73) is a potent agonist of adenylyl cyclase type 2 (AC2) with the EC50 of 90 nM. Adenylyl cyclase type 2 agonist-1 inhibits expression of Interleukin-6, making it a potential lead compound against respiratory diseases[1].

[Related Catalog]:

Signaling Pathways >> GPCR/G Protein >> Adenylate Cyclase
Research Areas >> Inflammation/Immunology

[References]

[1]. Guowei Xu, et al. The discovery, design and synthesis of potent agonists of adenylyl cyclase type 2 by virtual screening combining biological evaluation. Eur J Med Chem. 2020 Apr 1;191:112115.

Chemical & Physical Properties

[ Molecular Formula ]:
C27H17BrClNO5

[ Molecular Weight ]:
550.78

Related Compounds