Anti-MRSA agent 3

Names

[ CAS No. ]:
2416909-42-5

[ Name ]:
Anti-MRSA agent 3

Biological Activity

[Description]:

Anti-MRSA agent 3 (compound 18) has highly inhibitory activity against Methicillin-resistant Staphylococcus aureus (MRSA) with MIC of 0.098 μg/ml, and low cytotoxicity in normal cells. Anti-MRSA agent 3 has relatively strong ability to destroy bacterial cell wall and membrane, high binding affinity to bacterial genomic DNA[1].

[Related Catalog]:

Research Areas >> Infection
Signaling Pathways >> Anti-infection >> Bacterial

[Target]

MIC: 0.098 μg/ml (MRSA)[1]


[In Vivo]

Anti-MRSA agent 3 has potent efficacy at a dose of 10 mg/kg (20% survival) in a mouse peritonitis model[1].

[References]

[1]. Wang X, et al. Fascaplysin derivatives binding to DNA via unique cationic five-ring coplanar backbone showed potent antimicrobial/antibiofilm activity against MRSA in vitro and in vivo. Eur J Med Chem. 2022;230:114099.

Chemical & Physical Properties

[ Molecular Formula ]:
C29H18BrN3O2

[ Molecular Weight ]:
520.38

Related Compounds