AChE/BChE/MAO-B-IN-1

Names

[ CAS No. ]:
2416910-82-0

[ Name ]:
AChE/BChE/MAO-B-IN-1

Biological Activity

[Description]:

AChE/BChE/MAO-B-IN-1 (Compound 10) is a reversible and non-time-dependent AChE, BChE and MAO-B inhibitor with IC50 values of 7.31, 0.56 and 26.1 μM for hAChE, hBChE and hMAO-B, respectively. AChE/BChE/MAO-B-IN-1 can cross the BBB and shows neuroprotective effects without cytotoxicity[1].

[Related Catalog]:

Signaling Pathways >> Neuronal Signaling >> Monoamine Oxidase
Research Areas >> Neurological Disease
Signaling Pathways >> Neuronal Signaling >> AChE

[Target]

MAO-B:26.1 μM (IC50)

hAChE:7.31 μM (IC50)

hBChE:0.56 μM (IC50)


[In Vitro]

AChE/BChE/MAO-B-IN-1 (Compound 10) prevents amyloid β1-42 (Aβ1-42)-induced neuronal cell death[1].

[References]

[1]. Košak U, et al. N-alkylpiperidine carbamates as potential anti-Alzheimer's agents. Eur J Med Chem. 2020 Jul 1;197:112282.

Chemical & Physical Properties

[ Molecular Formula ]:
C20H24N2O2

[ Molecular Weight ]:
324.42

Related Compounds