FGFR4-IN-12

Names

[ CAS No. ]:
2423992-63-4

[ Name ]:
FGFR4-IN-12

Biological Activity

[Description]:

FGFR4-IN-12 (Compound A34) is a potent inhibitor of FGFR4. FGFR4-IN-12 exhibits improved FGFR4 inhibitory capability and selectivity and excellent anti-proliferative activities against FGFR4-dependent HCC cell lines. FGFR4-IN-12 has the potential for the research of cancer diseases[1].

[Related Catalog]:

Research Areas >> Cancer
Signaling Pathways >> Protein Tyrosine Kinase/RTK >> FGFR

[References]

[1]. Zhang X, et al. Discovery of 1,6-Naphthyridin-2(1H)-one Derivatives as Novel, Potent, and Selective FGFR4 Inhibitors for the Treatment of Hepatocellular Carcinoma. J Med Chem. 2022;65(11):7595-7618.

Chemical & Physical Properties

[ Molecular Formula ]:
C34H32Cl2N4O6

[ Molecular Weight ]:
663.55

Related Compounds