COX-1/2-IN-3

Names

[ CAS No. ]:
2428387-82-8

[ Name ]:
COX-1/2-IN-3

Biological Activity

[Description]:

COX-1/2-IN-3 (Compound 7a) is a COX-1 and COX-2 inhibitor. COX-2-IN-15 shows anti-inflammatory activity with low toxicity[1].

[Related Catalog]:

Research Areas >> Inflammation/Immunology
Signaling Pathways >> Immunology/Inflammation >> COX

[Target]

COX-1

COX-2


[In Vivo]

COX-1/2-IN-3 (Compound 7a) (1.25 and 0.625 mg/ear) exhibits a high level of in vivo anti-inflammatory activity, reducing ear edema and myeloperoxidase (MPO) activity[1].

[References]

[1]. Gonçalves DS, et al. Synthesis of novel 3,5,6-trisubstituted 2-pyridone derivatives and evaluation for their anti-inflammatory activity. Bioorg Med Chem. 2020 Jun 15;28(12):115549.

Chemical & Physical Properties

[ Molecular Formula ]:
C14H8N2O8

[ Molecular Weight ]:
332.22

Related Compounds