FGFR3-IN-2

Names

[ CAS No. ]:
2428742-58-7

[ Name ]:
FGFR3-IN-2

Biological Activity

[Description]:

FGFR3-IN-2 (compound 18b) is a potent and selective FGFR3 inhibitor, with IC50s of 4.1 nM and 570 nM for FGFR3 and VEGFR2, respectively. FGFR3-IN-2 can be used for the research of bladder cancer[1].

[Related Catalog]:

Research Areas >> Cancer
Signaling Pathways >> Protein Tyrosine Kinase/RTK >> FGFR
Signaling Pathways >> Protein Tyrosine Kinase/RTK >> VEGFR

[Target]

FGFR3:4.1 nM (IC50)

VEGFR2:570 nM (IC50)


[References]

[1]. Kuriwaki I, et, al. Structure-based drug design of 1,3,5-triazine and pyrimidine derivatives as novel FGFR3 inhibitors with high selectivity over VEGFR2. Bioorg Med Chem. 2020 May 15;28(10):115453.

Chemical & Physical Properties

[ Molecular Formula ]:
C28H39N9O4S

[ Molecular Weight ]:
597.73

Related Compounds