Nampt-IN-8

Names

[ CAS No. ]:
2453183-75-8

[ Name ]:
Nampt-IN-8

Biological Activity

[Description]:

Nampt-IN-8 (Compound 10d) is an NAMPT inhibitor with an IC50 of 0.183 μM. Nampt-IN-8 is also a relatively good NQO1 substrate. Nampt-IN-8 induces cell apoptosis and ROS[1].

[Related Catalog]:

Signaling Pathways >> Apoptosis >> Apoptosis
Research Areas >> Cancer
Signaling Pathways >> Protein Tyrosine Kinase/RTK >> ROS
Signaling Pathways >> Metabolic Enzyme/Protease >> Nampt

[Target]

IC50: 0.183 μM (NAMPT)[1]


[In Vitro]

Nampt-IN-8 (Compound 10d) shows antiproliferative activity with an IC50 of 1.15 μM[1].

[In Vivo]

Nampt-IN-8 (Compound 10d) (0-20 mg/kg) substantially inhibits the growth of A549/taxol xenograft tumors in vivo with no significant toxicity[1].

[References]

[1]. Zhang K, et al. Discovery of Small Molecules Simultaneously Targeting NAD(P)H:Quinone Oxidoreductase 1 and Nicotinamide Phosphoribosyltransferase: Treatment of Drug-Resistant Non-small-Cell Lung Cancer. J Med Chem. 2022 Jun 9;65(11):7746-7769.

Chemical & Physical Properties

[ Molecular Formula ]:
C36H35N3O4

[ Molecular Weight ]:
573.68

Related Compounds