Anticancer agent 72

Names

[ CAS No. ]:
2460167-51-3

[ Name ]:
Anticancer agent 72

Biological Activity

[Description]:

Anticancer agent 72 (compound 8c) is a potent inhibitor of K+ channel. Anticancer agent 72 induces apoptosis[1].

[Related Catalog]:

Signaling Pathways >> Apoptosis >> Apoptosis
Research Areas >> Cancer
Signaling Pathways >> Membrane Transporter/Ion Channel >> Potassium Channel

[In Vitro]

Anticancer agent 72 (compound 8c) has an inhibitory effects against PC3, MCF-7, HeLa, SKBr3 and A549 cells with IC50 values of 17.58, 5.55, 0.54, 11.13 and 20.40 μM[1].

[References]

[1]. Romero AH, et al. Anticancer potential of new 3-nitroaryl-6-(N-methyl)piperazin-1,2,4-triazolo[3,4-a]phthalazines targeting voltage-gated K+ channel: Copper-catalyzed one-pot synthesis from 4-chloro-1-phthalazinyl-arylhydrazones. Bioorg Chem. 2020 Aug;101:104031.

Chemical & Physical Properties

[ Molecular Formula ]:
C20H19N7O2

[ Molecular Weight ]:
389.41

Related Compounds