Aldose reductase-IN-6

Names

[ CAS No. ]:
2470019-41-9

[ Name ]:
Aldose reductase-IN-6

Biological Activity

[Description]:

Aldose reductase-IN-6 (Compound 3) is a competitive aldose reductase (AR) inhibitor with an IC50 of 3.164 μM and a Ki of 0.018 μM. Aldose reductase-IN-6 exhibits no cytotoxicity against healthy cells[1].

[Related Catalog]:

Signaling Pathways >> Metabolic Enzyme/Protease >> Aldose Reductase
Research Areas >> Metabolic Disease

[Target]

IC50: 3.164 μM (Aldose Reductase)[1]


[References]

[1]. Sever B, et al. Design, synthesis, in vitro and in silico investigation of aldose reductase inhibitory effects of new thiazole-based compounds. Bioorg Chem. 2020 Sep;102:104110.

Chemical & Physical Properties

[ Molecular Formula ]:
C20H16N4O2S

[ Molecular Weight ]:
376.43

Related Compounds