ATX inhibitor 14

Names

[ CAS No. ]:
2484811-39-2

[ Name ]:
ATX inhibitor 14

Biological Activity

[Description]:

ATX inhibitor 14 (compound 4), a indole-based carbamate derivative, is a potent autotaxin (ATX) inhibitor with an IC50 of 0.41 nM. ATX inhibitor 14 has the potential for fibrosis relevant diseases research[1].

[Related Catalog]:

Signaling Pathways >> Metabolic Enzyme/Protease >> Phosphodiesterase (PDE)
Research Areas >> Inflammation/Immunology

[Target]

Autotaxin:0.41 nM (IC50)


[References]

[1]. Hongrui Lei, et al. Structural and PK-guided identification of indole-based non-acidic autotaxin (ATX) inhibitors exhibiting high in vivo anti-fibrosis efficacy in rodent model. Eur J Med Chem. 2022 Jan 5;227:113951.

Chemical & Physical Properties

[ Molecular Formula ]:
C26H26Cl2N4O3S

[ Molecular Weight ]:
545.48

Related Compounds