ATX inhibitor 11

Names

[ CAS No. ]:
2485779-27-7

[ Name ]:
ATX inhibitor 11

Biological Activity

[Description]:

ATX inhibitor 11 (compound 13c) is a potent ATX (autotaxin) inhibitor, with an IC50 of 2.7 nM. ATX inhibitor 11 can typically alleviate the severity of fibrosis tissues and effectively reduce the deposition of fibrotic biomarker α-SMA in mice fibrosis model. ATX inhibitor 11 can be used for lung fibrosis research[1].

[Related Catalog]:

Signaling Pathways >> Metabolic Enzyme/Protease >> Phosphodiesterase (PDE)
Research Areas >> Others

[Target]

Autotaxin:2.7 ± 1 nM (IC50)


[References]

[1]. Lei H, et al. Novel imidazo[1,2-a]pyridine derivatives as potent ATX allosteric inhibitors: Design, synthesis and promising in vivo anti-fibrotic efficacy in mice lung model. Bioorg Chem. 2022 Mar;120:105590.

Chemical & Physical Properties

[ Molecular Formula ]:
C32H35N5O6

[ Molecular Weight ]:
585.65

Related Compounds