sEH/AChE-IN-4

Names

[ CAS No. ]:
2490589-12-1

[ Name ]:
sEH/AChE-IN-4

Biological Activity

[Description]:

sEH/AChE-IN-4 (compound (+)-15) is a potent and BBB-penetrated dual inhibitor of sEH (soluble epoxide hydrolase) and AChE (acetylcholinesterase), with IC50 values of 3.1 nM (hsEH), 1660 nM (hAChE), 179 nM (hBChE, human butyrylcholinesterase), 14.5 nM (msEH), and 102 nM (mAChE), respectively[1].

[Related Catalog]:

Research Areas >> Cancer
Research Areas >> Neurological Disease
Signaling Pathways >> Neuronal Signaling >> AChE

[Target]

IC50: 3.1 nM (hsEH), 1660 ± 450 nM (hAChE), 179 ± 26 nM (hBChE), 14.5 nM (msEH), 102 ± 18 nM (mAChE)[1]


[References]

[1]. Codony S, et al. Discovery and In Vivo Proof of Concept of a Highly Potent Dual Inhibitor of Soluble Epoxide Hydrolase and Acetylcholinesterase for the Treatment of Alzheimer's Disease. J Med Chem. 2022 Mar 24;65(6):4909-4925.

Chemical & Physical Properties

[ Molecular Formula ]:
C35H39ClF3N5O3

[ Molecular Weight ]:
670.16

Related Compounds