PI3K/mTOR Inhibitor-8

Names

[ CAS No. ]:
2492376-85-7

[ Name ]:
PI3K/mTOR Inhibitor-8

Biological Activity

[Description]:

PI3K/mTOR Inhibitor-8 (Compound 18b) is a PI3K and mTOR dual inhibitor with IC50 values of 0.46 nM and 12 nM against PI3Kα and mTOR, respectively. PI3K/mTOR Inhibitor-8 induces HCT-116 cells apoptosis and arrests cell cycle at the G1/S phase[1].

[Related Catalog]:

Signaling Pathways >> PI3K/Akt/mTOR >> mTOR
Research Areas >> Cancer
Signaling Pathways >> PI3K/Akt/mTOR >> PI3K

[Target]

PI3Kα:0.46 nM (IC50)

mTOR:12 nM (IC50)


[In Vitro]

PI3K/mTOR Inhibitor-8 (Compound 18b) shows anti-proliferation activities with IC50 values of 1.95 ± 0.02, 2.02 ± 0.01, 1.62 ± 0.01 and 1.55 ± 0.01 μM against PC-3, HCT-116, A549 and MDA-MB-231 cells, respectively[1].

[References]

[1]. Han Y, et al. Design, synthesis and biological evaluation of thieno[3,2-d]pyrimidine derivatives containing aroyl hydrazone or aryl hydrazide moieties for PI3K and mTOR dual inhibition. Bioorg Chem. 2020 Nov;104:104197.

Chemical & Physical Properties

[ Molecular Formula ]:
C23H22N8O4S

[ Molecular Weight ]:
506.54

Related Compounds