HIF-2α-IN-7

Names

[ CAS No. ]:
2511247-29-1

[ Name ]:
HIF-2α-IN-7

Biological Activity

[Description]:

HIF-2α-IN-7 is a hypoxia inducible factor 2α (HIF-2α) inhibitor. HIF-2α-IN-7 can inhibit HIF-2α with an EC50 value of 6nM. HIF-2α-IN-7 can be used for the research of various types of diseases including cancer, liver disease, inflammatory disease, pulmonary diseases and iron load disorders[1].

[Related Catalog]:

Research Areas >> Cancer
Research Areas >> Infection
Research Areas >> Inflammation/Immunology
Signaling Pathways >> Metabolic Enzyme/Protease >> HIF/HIF Prolyl-Hydroxylase
Research Areas >> Metabolic Disease

[Target]

EC50: 6nM (HIF-2α)[1]


[In Vitro]

HIF-2α-IN-7 has inhibitory activity for HIF-2α with an EC50 value of 6nM[1].

[References]

[1]. Jiping Fu, et al. Tetrahydro-1h-cyclopenta[cd]indene derivatives as hypoxia inducible factor-2(alpha) inhibitors. Patent. WO2020214853A1.

Chemical & Physical Properties

[ Molecular Formula ]:
C18H9F6NO2

[ Molecular Weight ]:
385.26

Related Compounds