EGFR-IN-59

Names

[ CAS No. ]:
2529891-44-7

[ Name ]:
EGFR-IN-59

Biological Activity

[Description]:

EGFR-IN-59 (Compound 8c) is a EGFR inhibitor (IC50=190 nM) and apoptosis inducer. EGFR-IN-59 exhibits cytotoxicity against non-small lung cancer cell lines (A549) and normal lung fibroblasts (WI38) with IC50s of 8.62 and 52.6 µM, respectively. EGFR-IN-59 can be used for the research of various cancers such as non-small cell lung cancer (NSCLC), head and neck cancer, breast cancer and colorectal cancer[1].

[Related Catalog]:

Signaling Pathways >> Apoptosis >> Apoptosis
Research Areas >> Cancer
Signaling Pathways >> JAK/STAT Signaling >> EGFR
Signaling Pathways >> Protein Tyrosine Kinase/RTK >> EGFR

[Target]

8.62 µM; 52.6 µM


[In Vitro]

EGFR-IN-59 (Compound 8c; 0-65.5 µM; 48 hours) shows cytotoxicity against non-small lung cancer cell lines (A549) and normal lung fibroblasts (WI38) [1]. Cell Viability Assay Cell Line: A549; WI38 cells[1] Concentration: 0-65.5 µM Incubation Time: 48 hours Result: Showed potent cytotoxicity against A549 cell line (IC50 = 8.62 µM), and mild to moderate toxicity against WI38 (IC50 = 52.6 µM).

[References]

[1]. Noha H Amin, et al. Design, synthesis and molecular modeling studies of 2-styrylquinazoline derivatives as EGFR inhibitors and apoptosis inducers. Bioorg Chem. 2020 Dec;105:104358.

Chemical & Physical Properties

[ Molecular Formula ]:
C27H23N5O4S

[ Molecular Weight ]:
513.57

Related Compounds