EphA2 agonist 1

Names

[ CAS No. ]:
2611459-57-3

[ Name ]:
EphA2 agonist 1

Biological Activity

[Description]:

EphA2 agonist 1 (Compound 7bg) is a potent EphA2 receptor agonist. EphA2 agonist 1 shows great potency and selectivity toward EphA2 overexpressed glioblastoma cells and stimulates EphA2 phosphorylation[1].

[Related Catalog]:

Research Areas >> Cancer
Signaling Pathways >> Protein Tyrosine Kinase/RTK >> Ephrin Receptor

[Target]

EphA2[1]


[In Vitro]

EphA2 agonist 1 (Compound 7bg) inhibits cell proliferation with IC50 values of 1.90 ± 0.55 μM and 7.91 ± 2.28 μM against U251 EphA2 overexpressed and U251 wild type cells, respectively[1].

[References]

[1]. Orahoske CM, et al. Dimeric small molecule agonists of EphA2 receptor inhibit glioblastoma cell growth. Bioorg Med Chem. 2020 Sep 15;28(18):115656.

Chemical & Physical Properties

[ Molecular Formula ]:
C50H58N12O12

[ Molecular Weight ]:
1019.07

Related Compounds