HIV-1 inhibitor-29

Names

[ CAS No. ]:
2642217-95-4

[ Name ]:
HIV-1 inhibitor-29

Biological Activity

[Description]:

HIV-1 inhibitor-29 (compound 14d2) is a potent HIV-1 inhibitor with an EC50 of 2.18 μM for HIV-1 IIIB. HIV-1 inhibitor-29 has high anti-resistance profile toward F227L/V106A strain (EC50 = 0.974 μM), and exhibits low cytotoxicity in MT-4 cells (CC50 = 211 μM). HIV-1 inhibitor-29 can be used for researching AIDS[1].

[Related Catalog]:

Signaling Pathways >> Anti-infection >> HIV
Research Areas >> Infection
Research Areas >> Inflammation/Immunology

[Target]

HIV (IIIB):2.18 μM (EC50)

HIV-1 (F227L/V106A):0.974 μM (EC50)


[References]

[1]. Wang Z, Kang D, Feng D, et al. Targeting dual tolerant regions of binding pocket: Discovery of novel morpholine-substituted diarylpyrimidines as potent HIV-1 NNRTIs with significantly improved water solubility. Eur J Med Chem. 2020;206:112811.

Chemical & Physical Properties

[ Molecular Formula ]:
C30H36N6O5

[ Molecular Weight ]:
560.64

Related Compounds