Axl-IN-6

Names

[ CAS No. ]:
2642224-22-2

[ Name ]:
Axl-IN-6

Biological Activity

[Description]:

Axl-IN-6 (compound 14) is an orally active and potent AXL inhibitor. Axl-IN-6 is well tolerated and significantly inhibits the tumor growth in MV-4-11 subcutaneous xenograft model[1].

[Related Catalog]:

Research Areas >> Cancer
Signaling Pathways >> Protein Tyrosine Kinase/RTK >> TAM Receptor

[Target]

AXL[1]


[References]

[1]. Zhang LL, et al. Discovery a series of quinazolin derivatives as potent AXL inhibitors. Eur J Med Chem. 2022 Apr 6;237:114316.[published online ahead of print, 2022 Apr 6]. Eur J Med Chem. 2022;237:114316.

Chemical & Physical Properties

[ Molecular Formula ]:
C32H36N4O

[ Molecular Weight ]:
492.65

Related Compounds