MODAG-001

Names

[ CAS No. ]:
2648041-72-7

[ Name ]:
MODAG-001

Biological Activity

[Description]:

MODAG-001 can bind to synuclein fibrils in a rat brain. MODAG-001 is a candidate α-syn imaging probe[1][2][3].

[Related Catalog]:

Signaling Pathways >> Others >> Others

Research Areas >> Neurological Disease

[In Vitro]

MODAG-001 shows strong binding affinity to recombinant human α-syn aggregates, but fail to bind real α-syn aggregates in human brain sections[2].

[References]

[1]. Bousiges O, et al. Biomarkers of Dementia with Lewy Bodies: Differential Diagnostic with Alzheimer's Disease. Int J Mol Sci. 2022 Jun 7;23(12):6371.

[2]. Bian J, et al. Discovery of styrylaniline derivatives as novel alpha-synuclein aggregates ligands. Eur J Med Chem. 2021 Dec 15;226:113887.

[3]. Akasaka T, et al. Synthesis and evaluation of novel radioiodinated phenylbenzofuranone derivatives as α-synuclein imaging probes. Bioorg Med Chem Lett. 2022 May 15;64:128679.

Chemical & Physical Properties

[ Molecular Formula ]:
C₁₆H₁₅BrN₄

[ Molecular Weight ]:
343.22

Related Compounds