STING agonist-9

Names

[ CAS No. ]:
2653337-73-4

[ Name ]:
STING agonist-9

Biological Activity

[Description]:

STING agonist-9 (Compound 45) is a potent STING agonist with an EC50 of 1.2 nM and 32.82 μM against h-STING and m-STING, respectively. STING agonist-9 shows antitumor activity[1].

[Related Catalog]:

Research Areas >> Cancer
Signaling Pathways >> Immunology/Inflammation >> STING

[Target]

EC50: 1.2 nM (h-STING), 32.82 μM (m-STING)[1]


[In Vitro]

STING agonist-9 (Compound 45) directly binds to various h-STING isoforms and m-STING[1]. STING agonist-9 potently activates both ISG and NF-κB signaling pathways[1].

[In Vivo]

STING agonist-9 (Compound 45) significantly inhibits the tumor growth in allograft 4T1 and CT26 tumor models by systemic administration, and induces tumor regression in CT26 tumor model without inducing weight loss[1].

[References]

[1]. Niu J, et al. Discovery of novel Thieno[2,3-d]imidazole derivatives as agonists of human STING for antitumor immunotherapy using systemic administration. Eur J Med Chem. 2022 Aug 5;238:114482.

Chemical & Physical Properties

[ Molecular Formula ]:
C39H47N13O6S

[ Molecular Weight ]:
825.94

Related Compounds