FGFR-IN-2

Names

[ CAS No. ]:
2665665-09-6

[ Name ]:
FGFR-IN-2

Biological Activity

[Description]:

FGFR-IN-2 (compound 1) is a potent FGFR inhibitor with IC50s of 7.3 nM, 4.3 nM, 7.6 nM, 11 nM for FGFR1, FGFR2, FGFR3 and FGFR4, respectively. FGFR-IN-2 has the potential for cancer research[1].

[Related Catalog]:

Research Areas >> Cancer
Signaling Pathways >> Protein Tyrosine Kinase/RTK >> FGFR

[Target]

FGFR1:7.3 nM (IC50)

FGFR2:4.3 nM (IC50)

FGFR3:7.6 nM (IC50)

FGFR4:11 nM (IC50)


[References]

[1]. Don Zhang, et al. Pyridazine and 1,2,4-triazine derivatives as fgfr kinase inhibitors. WO2021146163A1.

Chemical & Physical Properties

[ Molecular Formula ]:
C25H30N6O2

[ Molecular Weight ]:
446.54

Related Compounds