ATX inhibitor 20

Names

[ CAS No. ]:
2691937-03-6

[ Name ]:
ATX inhibitor 20

Biological Activity

[Description]:

ATX inhibitor 20 (compound 24) is a potent ATX (autotaxin) inhibitor, with an IC50 of 2.3 nM[1].

[Related Catalog]:

Research Areas >> Cancer

Signaling Pathways >> Metabolic Enzyme/Protease >> Phosphodiesterase (PDE)

[Target]

Autotaxin:2.3 ± 0.31 nM (IC50)

[References]

[1]. Jia F, et al. Structure-based linker exploration: Discovery of 1-ethyl-1H-indole analogs as novel ATX inhibitors. Bioorg Med Chem. 2020 Nov 15;28(22):115795.

Chemical & Physical Properties

[ Molecular Formula ]:
C₃₁H₃₄FN₅O₃

[ Molecular Weight ]:
543.63

Related Compounds