JNJ-4355

Names

[ CAS No. ]:
2697112-32-4

[ Name ]:
JNJ-4355

Biological Activity

[Description]:

JNJ-4355 is a highly potent MCL-1 (myeloid cell leukemia-1) inhibitor, with KI of 18 pM. JNJ-4355 shows antitumor activity[1][2].

[Related Catalog]:

Signaling Pathways >> Apoptosis >> Bcl-2 Family

Research Areas >> Cancer

[Target]

Mcl-1:18 pM (Ki)

[In Vitro]

JNJ-4355 shows promising in vitro potency data in cancer cell lines and AML patient-derived samples[2].

[In Vivo]

JNJ-4355 (IV , single) shows complete tumor regression in a mouse MOLP8 (multiple myeloma) xenograft[2].

[References]

[1]. Matthieu Jouffroy, et al. Synthesis of Atropisomeric Biaryls via Chiral Suzuki–Miyaura/Enzymatic Kinetic Resolution. ACS Catal. 2022, 12, 8380–8385.

[2]. Frederik J. Rombouts, et al. Abstract 2133: In pursuit of MCL-1 inhibitors with improved therapeutic window for the treatment of hematological malignancies: Discovery of JNJ-4355. Cancer Res (2022) 82 (12_Supplement): 2133.

Chemical & Physical Properties

[ Molecular Formula ]:
C₄₀H₄₃ClFN₅O₅S

[ Molecular Weight ]:
760.32

Related Compounds