HIV-1 integrase inhibitor 9

Names

[ CAS No. ]:
2709085-95-8

[ Name ]:
HIV-1 integrase inhibitor 9

Biological Activity

[Description]:

HIV-1 integrase inhibitor 9 (compound 8a) is a potent HIV-1 RNase H inhibitor with an IC50 of 12.3 μM. HIV-1 integrase inhibitor 9 shows an antiviral activity[1].

[Related Catalog]:

Signaling Pathways >> Anti-infection >> HIV
Research Areas >> Infection

[Target]

HIV-1 RNase H:12.3 nM (IC50)


[References]

[1]. Dongwei Kang, et al. Discovery, optimization, and target identification of novel coumarin derivatives as HIV-1 reverse transcriptase-associated ribonuclease H inhibitors. Eur J Med Chem. 2021 Dec 5;225:113769.

Chemical & Physical Properties

[ Molecular Formula ]:
C18H12N2O10

[ Molecular Weight ]:
416.30

Related Compounds