Metallo-β-lactamase-IN-4

Names

[ CAS No. ]:
2711044-25-4

[ Name ]:
Metallo-β-lactamase-IN-4

Biological Activity

[Description]:

Metallo-β-lactamase-IN-4 (compound 40) is a potent metallo-β-lactamases (MBL) inhibitor, with IC50 values of 0.5 μM (VIM-1), 2.1 μM (NDM-1), and 3.3 μM (IMP-7), respectively[1].

[Related Catalog]:

Research Areas >> Infection
Signaling Pathways >> Anti-infection >> Bacterial

[Target]

IC50: 0.5 ± 0.0 μM (VIM-1), 2.1 ± 0.1 μM (NDM-1), 3.3 ± 0.4 μM (IMP-7)[1]


[References]

[1]. Kaya C, et al. N-Aryl Mercaptopropionamides as Broad-Spectrum Inhibitors of Metallo-β-Lactamases. J Med Chem. 2022 Mar 10;65(5):3913-3922.

Chemical & Physical Properties

[ Molecular Formula ]:
C10H14N4O3S2

[ Molecular Weight ]:
302.37

Related Compounds