AChE/BuChE-IN-3

Names

[ CAS No. ]:
2742707-47-5

[ Name ]:
AChE/BuChE-IN-3

Biological Activity

[Description]:

AChE/BuChE-IN-3 (compound C4) is a potent and blood-brain barrier (BBB) penetrant AChE and BuChE dual inhibitor with IC50s of 0.65 μM and 5.77 μM for AChE and BuChE. AChE/BuChE-IN-3 also inhibits Aβ1-42 aggregation. AChE/BuChE-IN-3 has effectively neuroprotective activities and nearly no toxicity on SH-SY5Y cells. AChE/BuChE-IN-3 can be used for researching Alzheimer's disease[1].

[Related Catalog]:

Research Areas >> Cancer
Signaling Pathways >> Neuronal Signaling >> AChE

[Target]

IC50: 5.77 μM (BuChE), 0.65 μM (AChE)[1]


[In Vitro]

AChE/BuChE-IN-3 (compound C4) (12.5-100 μM; 48 hours) exhibits no cytotoxicity on the human neuroblastoma cell line SH-SY5Y, and slightly increases cell viabilities[1]. Cell Viability Assay Cell Line: SH-SY5Y[1] Concentration: 12.5 μM, 25 μM, 50 μM and 100 μM Incubation Time: 48 hours Result: Exhibited no cytotoxicity on the human neuroblastoma cell line SH-SY5Y, and slightly increased cell viabilities.

[References]

[1]. Shi S, et al. Semi-synthesis and biological evaluation of flavone hybrids as multifunctional agents for the potential treatment of Alzheimer's disease. Bioorg Chem. 2020 Jul;100:103917.

Chemical & Physical Properties

[ Molecular Formula ]:
C30H30F3N3O6

[ Molecular Weight ]:
585.57

Related Compounds