Metallo-β-lactamase-IN-7

Names

[ CAS No. ]:
2752453-58-8

[ Name ]:
Metallo-β-lactamase-IN-7

Biological Activity

[Description]:

Metallo-β-lactamase-IN-7 is a potent VIM-Type metallo-β-lactamase inhibitor with IC50s of 0.019 μM, 13.64 μM, 0.38 μM for VIM-2, VIM-1 and VIM-5. Metallo-β-lactamase-IN-7 potentiate antibacterial activity of Meropenem against the Gram-negative bacterial strains[1].

[Related Catalog]:

Research Areas >> Infection
Signaling Pathways >> Anti-infection >> Bacterial

[Target]

IC50: 0.019 μM (VIM-2), 13.64 μM (VIM-1), 0.38 μM (VIM-5)[1]


[In Vitro]

Metallo-β-lactamase-IN-7 (compound 59) (10 μM; 18 - 20 hours) can potentiate Meropenem activity against VIM-2 mediated antibacterial resistance with FIC index values of 0.02[1]. Metallo-β-lactamase-IN-7 (100 μM) potentiates the antibacterial activity of Meropenem against PA W35 with FIC index values of 0.125[1].

[References]

[1]. Yan YH, Li W, Chen W, et al. Structure-guided optimization of 1H-imidazole-2-carboxylic acid derivatives affording potent VIM-Type metallo-β-lactamase inhibitors. Eur J Med Chem. 2022;228:113965.

Chemical & Physical Properties

[ Molecular Formula ]:
C12H10N4O2S

[ Molecular Weight ]:
274.30

Related Compounds