HIV-1 inhibitor-15

Names

[ CAS No. ]:
2757182-99-1

[ Name ]:
HIV-1 inhibitor-15

Biological Activity

[Description]:

HIV-1 inhibitor-15 (compound 9d) is a highly potent and broad-spectrum HIV-1 inhibitor. HIV-1 inhibitor-15 has inhibitory activity against HIV-1 WT, L100I, K103N, Y181C, E138K with EC50s of 1.7 nM, 4 nM, 2 nM, 6 nM and 9 nM, respectively. HIV-1 inhibitor-15 has good solubility, safety profiles and favorable oral bioavailability[1].

[Related Catalog]:

Signaling Pathways >> Anti-infection >> HIV
Research Areas >> Infection

[Target]

HIV-1 (WT):1.7 nM (EC50)

HIV-1 (L100I):4 nM (EC50)

HIV-1 (K103N):2 nM (EC50)

HIV-1 (Y181C):6 nM (EC50)

HIV-1 (E138K):9 nM (EC50)


[References]

[1]. Ding L, et al. Discovery of Novel Pyridine-Dimethyl-Phenyl-DAPY Hybrids by Molecular Fusing of Methyl-Pyrimidine-DAPYs and Difluoro-Pyridinyl-DAPYs: Improving the Druggability toward High Inhibitory Activity, Solubility, Safety, and PK. J Med Chem. 2022;65(3):2122-2138.

Chemical & Physical Properties

[ Molecular Formula ]:
C24H20N6

[ Molecular Weight ]:
392.46

Related Compounds