SARS-CoV-2-IN-35

Names

[ CAS No. ]:
2757763-47-4

[ Name ]:
SARS-CoV-2-IN-35

Biological Activity

[Description]:

SARS-CoV-2-IN-35 is a potent and orally active SARS-CoV-2 M pro inhibitor with a Ki value of 12.1 nM. SARS-CoV-2-IN-35 can be used in research of COVID-19[1].

[Related Catalog]:

Research Areas >> Infection
Signaling Pathways >> Anti-infection >> SARS-CoV

[In Vivo]

SARS-CoV-2-IN-35 (compound 5; 10 mg/kg; p.o.) has good oral utilization in Wistar-Han rats[1]. Animal Model: Wistar-Han rats[1] Dosage: 10 mg/kg Administration: Oral administration Result: Had oral F of 33 %.

[References]

[1]. Owen DR, et, al. An oral SARS-CoV-2 Mpro inhibitor clinical candidate for the treatment of COVID-19. Science. 2021 Dec 24;374(6575):1586-1593.  

Chemical & Physical Properties

[ Molecular Formula ]:
C29H34F3N5O5S

[ Molecular Weight ]:
621.67

Related Compounds