KRAS G12C inhibitor 49

Names

[ CAS No. ]:
2761380-32-7

[ Name ]:
KRAS G12C inhibitor 49

Biological Activity

[Description]:

KRAS G12C inhibitor 49 (Compound 3-2M) is an orally active KRAS G12C inhibitor. KRAS G12C inhibitor 49 shows antitumor activity[1].

[Related Catalog]:

Research Areas >> Cancer
Signaling Pathways >> GPCR/G Protein >> Ras

[Target]

KRAS(G12C)


[In Vitro]

KRAS G12C inhibitor 49 (Compound 3-2M) shows antiproliferative activity against MIAPaCa-2 and H358 with IC50 values of both 0-50 nM[1].

[References]

[1]. ZHANG Qiang, et al. Aromatic compound and application thereof in antitumor drug. WO2022028346A1.

Chemical & Physical Properties

[ Molecular Formula ]:
C31H31ClN6O3

[ Molecular Weight ]:
571.07

Related Compounds