Mpro/PLpro-IN-1

Names

[ CAS No. ]:
2766185-78-6

[ Name ]:
Mpro/PLpro-IN-1

Biological Activity

[Description]:

Mpro/PLpro-IN-1 (Compound 29) is a potent inhibitor of Mpro/PLpro. Mpro/PLpro-IN-1 is a dual acting SARS-CoV-2 proteases inhibitor featuring micromolar inhibitory potency versus Mpro (IC50 = 1.72 μM) and submicromolar potency versus PLpro (IC50 = 0.67 μM)[1].

[Related Catalog]:

Research Areas >> Infection
Signaling Pathways >> Others >> Others

[References]

[1]. Di Sarno V, et al. Identification of a dual acting SARS-CoV-2 proteases inhibitor through in silico design and step-by-step biological characterization. Eur J Med Chem. 2021;226:113863.

Chemical & Physical Properties

[ Molecular Formula ]:
C25H27ClN4O3

[ Molecular Weight ]:
466.96

Related Compounds