HL-8

Names

[ CAS No. ]:
2766352-64-9

[ Name ]:
HL-8

Biological Activity

[Description]:

HL-8 is a PROTAC molecule targeting PI3K kinase. HL-8 has a significant and complete degradation effect on PI3K kinase at a concentration of 10 μM within 8 h. HL-8 has the potential for the research of cancer diseases[1].

[Related Catalog]:

Research Areas >> Cancer
Signaling Pathways >> PI3K/Akt/mTOR >> PI3K

[References]

[1]. Wang H, et al. Design, synthesis and activity study of a novel PI3K degradation by hijacking VHL E3 ubiquitin ligase. Bioorg Med Chem. 2022 May 1;61:116707.

Chemical & Physical Properties

[ Molecular Formula ]:
C57H59F2N11O9S2

[ Molecular Weight ]:
1144.27

Related Compounds