SARS-CoV-2 Mpro-IN-6

Names

[ CAS No. ]:
2768834-48-4

[ Name ]:
SARS-CoV-2 Mpro-IN-6

Biological Activity

[Description]:

SARS-CoV-2 Mpro-IN-6 is a covalent, irreversible and selective SARS-CoV-2 Mpro inhibitor with an IC50 of 0.18 μM. SARS-CoV-2 Mpro-IN-6 does not inhibit human cathepsins B, F, K, and L, and caspase 3[1].

[Related Catalog]:

Research Areas >> Infection
Signaling Pathways >> Anti-infection >> SARS-CoV

[Target]

IC50: 0.18 μM (SARS-CoV-2 Mpro)[1]


[In Vitro]

SARS-CoV-2 Mpro-IN-6 (GD-9) 对 SARS-CoV-2 显示出良好的抗病毒效力 (ECsub>50 = 2.64 μM)。SARS-CoV-2 Mpro-IN-6 在 Vero E6 细胞 中表现出一定的细胞毒性（CCsub>50 为 12.51 μM）[1]。

[References]

[1]. Shenghua Gao, et al. Discovery and Crystallographic Studies of Nonpeptidic Piperazine Derivatives as Covalent SARS-CoV-2 Main Protease Inhibitors. J Med Chem. 2022 Dec 22;65(24):16902-16917.  

Chemical & Physical Properties

[ Molecular Formula ]:
C18H18Cl3N3O2S

[ Molecular Weight ]:
446.78

Related Compounds