AIE-Cbz-LD-C7

AIECbz-LD-C7 is an aggregation-induced emission (AIE) probe based on the conjugation of quinoline-malononitrile (QM) and carbazole. AIECbz-LD-C7 has excellent LD-specificity. AIECbz-LD-C7 can be used for tracking the dynamic changes of LDs and studying the association between LDs and lysosome/endoplasmic reticulum (ER)[1].

Research Areas >> Others

Signaling Pathways >> Others >> Others

AIE-Cbz-LD-C (0, 2, 5, 10, 20, and 30 μM; 24 h) have excellent biocompatibility[1]. AIECbz-LD-C7 (0.5 μM, 15 min) could aggregate in LDs accurately and light up the LDs with good photostability[1]. AIE-Cbz-LD-C7 (0.5 μM) can be used to visualize the interplay between LDs and lysosomes during lipophag due to the excellent LD-specificity[1]. AIE-Cbz-LD-C7 (0.5 μM, 15 min) increases the number of ferroptosis[1]. Cell Cytotoxicity Assay[1] Cell Line: HepG2 cells Concentration: 0, 2, 5, 10, 20, and 30 μM Incubation Time: 24 h Result: Displayed favorable viability with a value above 90%.

[1]. Rui Chen, et al. Rational Design of Novel Lipophilic Aggregation-Induced Emission Probes for Revealing the Dynamics of Lipid Droplets during Lipophagy and Ferroptosis. Anal Chem. 2022 Sep 19.